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Skeletal muscle of stroke-prone spontaneously hypertensive rats exhibits reduced insulin-stimulated glucose transport and elevated levels of caveolin and flotillin.

Diabetes - 1 Sept 2001

James D J, Cairns F, Salt I P, Murphy G J, Dominiczak A F, Connell J M, Gould G W

Abstract excerpt

Insulin resistance is of major pathogenic importance in several common human disorders, but the underlying mechanisms are unknown. The stroke-prone spontaneously hypertensive (SHRSP) rat is a model of human insulin resistance and is characterized by reduced insulin-mediated glucose disposal and defective fatty acid metabolism in isolated adipocytes (Collison et al. [Diabetes 49:2222-2226, 2000]). In this study,...

Topics

Animals
Caveolin 1
Caveolins
Cells, Cultured
Genetic Predisposition to Disease
Insulin
Male
Membrane Proteins
Monosaccharide Transport Proteins
Muscle, Skeletal
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred SHR

Rats, Inbred WKY

Stroke

Source

Identifiers

PMID: 11522683
DOI: 10.2337/diabetes.50.9.2148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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