Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors.

Journal of the American Heart Association - 16 Feb 2018

Davel Ana P, Lu Qing, Moss M Elizabeth, Rao Sitara, Anwar Imran J, DuPont Jennifer J, Jaffe Iris Z

Abstract excerpt

BACKGROUND: The incidence of obesity is rising, particularly among women. Microvascular dysfunction is more common with female sex, obesity, and hyperlipidemia and predicts adverse cardiovascular outcomes, but the molecular mechanisms are unclear. Because obesity is associated with mineralocorticoid receptor (MR) activation, we tested the hypothesis that MR in endothelial cells contribute to sex differences in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Factors
Share to Hyperlipidemias

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nitric Oxide Synthase Type III

Share to Proprotein Convertase 9

Share to Receptors, Mineralocorticoid

Share to Small-Conductance Calcium-Activated Potassium Channels

Share to Superoxides

Share to Vasodilation

Source

Open in PubMed Open full text

Identifiers

PMID: 29453308
DOI: 10.1161/JAHA.117.007675
PMCID: PMC5850194

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors.PMID 29453308Read ↗

Obesity-Related Hypertension: An Emerging Clinical Phenotype.Semantic proximity Read ↗

Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female miceSemantic proximity Read ↗

Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species.Semantic proximity Read ↗

Sexual dimorphism of metabolic and vascular dysfunction in aged mice and those lacking the sphingosine 1-phosphate receptor 3.Semantic proximity Read ↗

How Structure, Mechanics, and Function of the Vasculature Contribute to Blood Pressure Elevation in Hypertension.Semantic proximity Read ↗

Endothelial nitric oxide synthase and endothelial dysfunction.Semantic proximity Read ↗

Epigenetic Remodeling in Obesity-Related Vascular DiseaseSemantic proximity Read ↗

MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapySemantic proximity Read ↗

Sex-based differences in vascular function.Semantic proximity Read ↗

The Effect of High Fat Diet and H2S Donor GYY-4137 on Vascular Function in Spontaneously Hypertensive RatsSemantic proximity Read ↗

Effect of endothelium-specific insulin resistance on endothelial function in vivo.Semantic proximity Read ↗

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.