Article
Phenotypic consequences of a nonsense mutation in the leptin receptor gene (fak) in obese spontaneously hypertensive Koletsky rats (SHROB).
The Journal of nutrition - 1 Dec 1998
Ishizuka T, Ernsberger P, Liu S, Bedol D, Lehman T M, Koletsky R J, Friedman J E
Abstract excerpt
The genetically obese Koletsky rat (SHROB, fak) has a novel point mutation of the leptin receptor at amino acid +763, resulting in a premature stop codon in the leptin receptor extracellular domain. This implies that all leptin receptor isoforms should be absent in this model. We examined the phe...
Topics
- Animals
- Carrier Proteins
- Female
- Glucose
- Humans
- Leptin
- Male
- Muscle, Skeletal
- Obesity
- Phenotype
- Point Mutation
- Proteins
- RNA, Messenger
- Rats
- Rats, Inbred SHR
- Rats, Mutant Strains
- Receptors, Cell Surface
- Receptors, Leptin