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Article

Smoothened activates Galphai-mediated signaling in frog melanophores.

The Journal of biological chemistry - 25 Aug 2000

DeCamp D L, Thompson T M, de Sauvage F J, Lerner M R

Abstract excerpt

The 7-pass transmembrane protein Smoothened was investigated for its ability to act as a G-protein-coupled receptor in Xenopus laevis melanophores. A plasmid containing the human Smoothened cDNA insert was transfected into immortalized frog pigment cells. Cells expressing the protein showed a phenotype of persistent pigment aggregation, a hallmark of constitutive Galpha(i) activation. Smoothened-mediated pigment...

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Share to GTP-Binding Protein alpha Subunits, Gi-Go
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10835429
DOI: 10.1074/jbc.M004055200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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