Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.

Molecular biology of the cell - 1 Dec 2008

Philipp Melanie, Fralish Gregory B, Meloni Alison R, Chen Wei, MacInnes Alyson W, Barak Lawrence S, Caron Marc G

Abstract excerpt

Smoothened, a heptahelical membrane protein, functions as the transducer of Hedgehog signaling. The kinases that modulate Smoothened have been thoroughly analyzed in flies. However, little is known about how phosphorylation affects Smoothened in vertebrates, mainly, because the residues, where Smoothened is phosphorylated are not conserved from Drosophila to vertebrates. Given its molecular architecture,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Hedgehog Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Receptors, G-Protein-Coupled

Share to Smoothened Receptor

Share to Transcription, Genetic

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18815277
DOI: 10.1091/mbc.e08-05-0448
PMCID: PMC2592680

Genes

GRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.PMID 18815277Read ↗

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.Semantic proximity Read ↗

Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling.Semantic proximity Read ↗

Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development.Semantic proximity Read ↗

Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.Semantic proximity Read ↗

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling.Semantic proximity Read ↗

Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.Semantic proximity Read ↗

The Drosophila G-protein-coupled receptor kinase homologue Gprk2 is required for egg morphogenesis.Semantic proximity Read ↗

The mechanisms of Hedgehog signalling and its roles in development and diseaseSemantic proximity Read ↗

Regulation of the oncoprotein Smoothened by small molecules.Semantic proximity Read ↗

Grainyhead-like (Grhl) Target Genes in Development and CancerSemantic proximity Read ↗

A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development.Semantic proximity Read ↗

Extensive crosstalk of G protein-coupled receptors with the Hedgehog signalling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.