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Article

A dominant negative mutation in two proteins created by ectopic expression of an AU-rich 3' untranslated region.

Somatic cell and molecular genetics - 1 Mar 1990

Bunnell B A, Fillmore H, Gregory P, Kidd V J

Abstract excerpt

We have found that the ectopic expression of a specific gene's 3' untranslated region leads to the dose dependent loss, relative to gene copy number, of that specific mRNA and protein, as well as an associated protein, in a eukaryotic cell line. The loss of these proteins from the eukaryotic cell line also results in specific phenotypic changes in these cells, suggesting that we have created a dominant negative...

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PMID: 2108505
DOI: 10.1007/BF01233045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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