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Article

A novel mechanism of tumor suppression by destabilizing AU-rich growth factor mRNA.

Oncogene - 5 Jun 2003

Stoecklin Georg, Gross Brigitte, Ming Xiu-Fen, Moroni Christoph

Abstract excerpt

The occurrence of pathologically stable mRNAs of proto-oncogenes, growth factors and cyclins has been proposed to contribute to experimental and human oncogenesis. In normal resting cells, mRNAs containing an AU-rich element (ARE) in their 3' untranslated region are subjected to rapid degradation. Tristetraprolin (TTP) is an RNA-binding zinc-finger protein that promotes decay of ARE-containing mRNAs. Here we...

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Identifiers

PMID: 12789264
DOI: 10.1038/sj.onc.1206418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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