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Article

A new feature of Mpl receptor: ligand-induced transforming activity in FRE rat fibroblasts.

Oncogene - 13 Apr 2000

Challier C, Cocault L, Flon M, Pauchard M, Porteu F, Gisselbrecht S, Souyri M

Abstract excerpt

Mpl is the receptor for thrombopoietin, the primary regulator of platelet production by megakaryocytes. Upon stimulation by its ligand, Mpl receptor induces proliferation and differentiation of hematopoietic cell lines of various origins. In this paper, we show that Mpl is also able to transform FRE rat fibroblasts in the presence of MGDF (pegylated Megakaryocyte Growth and Development Factor), a modified form of...

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Identifiers

PMID: 10803464
DOI: 10.1038/sj.onc.1203472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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