Article
A new feature of Mpl receptor: ligand-induced transforming activity in FRE rat fibroblasts.
Oncogene - 13 Apr 2000
Challier C, Cocault L, Flon M, Pauchard M, Porteu F, Gisselbrecht S, Souyri M
Abstract excerpt
Mpl is the receptor for thrombopoietin, the primary regulator of platelet production by megakaryocytes. Upon stimulation by its ligand, Mpl receptor induces proliferation and differentiation of hematopoietic cell lines of various origins. In this paper, we show that Mpl is also able to transform FRE rat fibroblasts in the presence of MGDF (pegylated Megakaryocyte Growth and Development Factor), a modified form of...
Topics
- 3T3 Cells
- Adaptor Proteins, Signal Transducing
- Adaptor Proteins, Vesicular Transport
- Animals
- Cell Transformation, Neoplastic
- Cytoplasm
- DNA-Binding Proteins
- Fibroblasts
- Genetic Vectors
- Janus Kinase 2
- Leukemia Virus, Murine