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Article

Structural and functional properties of platelet-derived growth factor and stem cell factor receptors.

Cold Spring Harbor perspectives in biology - 1 Aug 2013

Heldin Carl-Henrik, Lennartsson Johan

Abstract excerpt

The receptors for platelet-derived growth factor (PDGF) and stem cell factor (SCF) are members of the type III class of PTK receptors, which are characterized by five Ig-like domains extracellularly and a split kinase domain intracellularly. The receptors are activated by ligand-induced dimerization, leading to autophosphorylation on specific tyrosine residues. Thereby the kinase activities of the receptors are...

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Identifiers

PMID: 23906712
DOI: 10.1101/cshperspect.a009100
PMCID: PMC3721287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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