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Article

Structural and functional properties of platelet-derived growth factor and stem cell factor receptors.

Cold Spring Harbor perspectives in biology - 1 Aug 2013

Heldin Carl-Henrik, Lennartsson Johan

Abstract excerpt

The receptors for platelet-derived growth factor (PDGF) and stem cell factor (SCF) are members of the type III class of PTK receptors, which are characterized by five Ig-like domains extracellularly and a split kinase domain intracellularly. The receptors are activated by ligand-induced dimerization, leading to autophosphorylation on specific tyrosine residues. Thereby the kinase activities of the receptors are...

Topics

Dimerization
Embryonic Development
Homeostasis
Membrane Proteins
Mutation
Neoplasms
Phosphorylation
Protein Structure, Tertiary
Proto-Oncogene Proteins c-kit
Receptors, Colony-Stimulating Factor
Receptors, Platelet-Derived Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

Substrate Specificity

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Identifiers

PMID: 23906712
DOI: 10.1101/cshperspect.a009100
PMCID: PMC3721287

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