Article
Thrombopoietin signal transduction: studies from cell lines and primary cells.
Methods (San Diego, Calif.) - 1 Mar 1999
Drachman J G, Rojnuckarin P, Kaushansky K
Abstract excerpt
Thrombopoietin (TPO) and its receptor Mpl support all of the developmental step necessary for megakaryocytopoiesis. In the past few years, the signaling pathways utilized by this member of the cytokine receptor family have been extensively studied, especially JAK/STAT, Ras/MAP kinase, Shc, and other adapter molecules. Many if not most of the secondary signaling pathways activated by thrombopoietin have also been...
Topics
- Animals
- Cell Differentiation
- Cell Line
- Cytokines
- DNA-Binding Proteins
- Electrophoresis
- Flow Cytometry
- Humans
- Janus Kinase 2
- Megakaryocytes
- Mice
- Mice, Transgenic
- Molecular Biology
- Mutation
- Neoplasm Proteins
- Ploidies
- Protein-Tyrosine Kinases
- Proteins