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Article

The mechanism of cell membrane ruffling relies on a phospholipase D2 (PLD2), Grb2 and Rac2 association.

Cellular signalling - 1 Aug 2011

Mahankali Madhu, Peng Hong-Juan, Cox Dianne, Gomez-Cambronero Julian

Abstract excerpt

Membrane ruffling is the formation of actin rich membrane protrusions, essential for cell motility. The exact mechanism of ruffling is not fully known. Using YFP and CFP fluorescent chimeras, we show for the first time a co-localization of Phospholipase D2 (PLD2) and Growth factor Receptor Bound protein-2 (Grb2) with actin-rich membrane protrusions of macrophages. Grb2 cooperates with PLD2 in enhancing membrane...

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Source

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Identifiers

PMID: 21419846
DOI: 10.1016/j.cellsig.2011.03.010
PMCID: PMC3095729

Genes

PLD2
CFP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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