Article

The Influence of Overexpressed Fibroblast Growth Factor Receptors Towards Vitamin D Receptor Expression and Activity

2021-10-21

Abstract excerpt

(1) Background: Many malignancies are driven by mutations which affect the gene for fibroblast growth factor receptor (FGFR) 1. Previously we have documented that signal transduction from FOP2–FGFR1 fusion protein in KG1 cells downregulated the expression of vitamin D receptor (VDR) gene. In this paper we investigated if also other FGFRs were responsible for the regulation of the VDR expression. (2) Methods:...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b1c249eb-c4af-5618-8f25-aaae76078451
DOI: 10.20944/preprints202110.0304.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Influence of Overexpressed Fibroblast Growth Factor Receptors Towards Vitamin D Receptor Expression and ActivityDOI 10.20944/preprints202110.0304.v1Read

Fibroblast growth factor receptor 1 promotes MG63 cell proliferation and is associated with increased expression of cyclin-dependent kinase 1 in osteosarcomaSemantic proximity Read

1,25-Dihydroxyvitamin D3 induces monocytic differentiation of human myeloid leukemia cells by regulating C/EBPβ expression through MEF2CSemantic proximity Read

FRAG1, a gene that potently activates fibroblast growth factor receptor by C-terminal fusion through chromosomal rearrangement.Semantic proximity Read

Gene expression analysis of 1,25(OH)<sub>2</sub>D<sub>3</sub>‐dependent differentiation of HL‐60 cells: a cDNA array studySemantic proximity Read

FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells.Semantic proximity Read

The receptor tyrosine kinase FGFR2b/KGFR controls early differentiation of human keratinocytes.Semantic proximity Read

Functions of fibroblast growth factors and their receptors.Semantic proximity Read

A new feature of Mpl receptor: ligand-induced transforming activity in FRE rat fibroblasts.Semantic proximity Read

Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail.Semantic proximity Read

Novel Role of Vitamin K2: A Potent Inducer of Differentiation of Various Human Myeloid Leukemia Cell LinesSemantic proximity Read

The MAPK ERK5, but not ERK1/2, inhibits the progression of monocytic phenotype to the functioning macrophage.Semantic proximity Read

The FGFRL1 receptor is shed from cell membranes, binds fibroblast growth factors (FGFs), and antagonizes FGF signaling in Xenopus embryos.Semantic proximity Read