Article
Platelet-derived growth factor receptor-beta (PDGFR-beta) activation promotes its association with the low density lipoprotein receptor-related protein (LRP). Evidence for co-receptor function.
The Journal of biological chemistry - 29 Jul 2005
Newton Christopher S, Loukinova Elena, Mikhailenko Irina, Ranganathan Sripriya, Gao Yamei, Haudenschild Christian, Strickland Dudley K
Abstract excerpt
Activation of the platelet-derived growth factor receptor-beta (PDGFR-beta) leads to tyrosine phosphorylation of the cytoplasmic domain of LRP and alters its association with adaptor and signaling proteins, such as Shc. The mechanism of the PDGF-induced LRP tyrosine phosphorylation is not well understood, especially since PDGF not only activates PDGF receptor but also binds directly to LRP. To gain insight into...
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