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Article

Studies of the c-Mpl thrombopoietin receptor through gene disruption and activation.

Stem cells (Dayton, Ohio) - 1 Jan 1996

Alexander W S, Roberts A W, Maurer A B, Nicola N A, Dunn A R, Metcalf D

Abstract excerpt

The c-mpl gene encodes a receptor for thrombopoietin (TPO), a cytokine that potently stimulates megakaryocytopoiesis. To study the mechanisms of c-Mpl activation, we generated constitutively active receptor mutants. Substitution of cysteine residues into a dimer interface homology domain of c-Mpl forced ligand-independent homodimerization and constitutive receptor activation. In factor-dependent cells, mutant...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11012212
DOI: 10.1002/stem.5530140716

Genes

TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Studies of the c-Mpl thrombopoietin receptor through gene disruption and activation.PMID 11012212Read ↗

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