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Article

Molecular Mechanism of Mutant CALR-Mediated Transformation.

Cancer discovery - 1 Apr 2016

Stanley Robert F, Steidl Ulrich

Abstract excerpt

Elf and colleagues used an elegant series of functional and biochemical assays to investigate the molecular mechanism of mutant calreticulin (CALR)-driven cellular transformation in myeloproliferative neoplasms (MPN). Mutant CALR is sufficient to induce MPN in mouse transplantation experiments, and transformation is dependent upon physical interaction mediated by the positive electrostatic charge of the mutant...

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Topics

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Share to Cell Transformation, Neoplastic
Share to CALR gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myeloproliferative Disorders

Source

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Identifiers

PMID: 27045016
DOI: 10.1158/2159-8290.CD-16-0238
PMCID: PMC4832981

Genes

CALR
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Molecular Mechanism of Mutant CALR-Mediated Transformation.PMID 27045016Read ↗

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