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Article

Top-down motif engineering of a cytokine receptor for directing ex vivo expansion of hematopoietic stem cells.

Journal of biotechnology - 1 Dec 2013

Saka Koichiro, Kawahara Masahiro, Teng Jinying, Otsu Makoto, Nakauchi Hiromitsu, Nagamune Teruyuki

Abstract excerpt

The technique to expand hematopoietic stem cells (HSCs) ex vivo is eagerly anticipated to secure an enough amount of HSCs for clinical applications. Previously we developed a scFv-thrombopoietin receptor (c-Mpl) chimera, named S-Mpl, which can transduce a proliferation signal in HSCs in response to a cognate antigen. However, a remaining concern of the S-Mpl chimera may be the magnitude of the cellular expansion...

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Source

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PMID: 24070902
DOI: 10.1016/j.jbiotec.2013.09.012

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STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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