Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways.

Molecular and cellular biology - 1 Apr 2001

Garcia J, de Gunzburg J, Eychène A, Gisselbrecht S, Porteu F

Abstract excerpt

Thrombopoietin (TPO) regulates growth and differentiation of megakaryocytes. We previously showed that extracellular signal-regulated kinases (ERKs) are required for TPO-mediated full megakaryocytic maturation in both normal progenitors and a megakaryoblastic cell line (UT7) expressing the TPO receptor (Mpl). In these cells, intensity and duration of TPO-induced ERK signal are controlled by several regions of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Activation
Share to Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-raf

Share to rap1 GTP-Binding Proteins

Share to ras Proteins

Share to Receptors, Cytokine

Share to Receptors, Thrombopoietin

Share to Thrombopoietin

Source

Open in PubMed Open full text

Identifiers

PMID: 11283246
DOI: 10.1128/MCB.21.8.2659-2670.2001
PMCID: PMC86897

Genes

TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways.PMID 11283246Read ↗

Insights into Regulatory Factors in Megakaryocyte Development and Function: Basic Mechanisms and Potential TargetsSemantic proximity Read ↗

Thrombopoietin signal transduction: studies from cell lines and primary cells.Semantic proximity Read ↗

Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis.Semantic proximity Read ↗

Thrombopoietin regulates IEX-1 gene expression through ERK-induced AML1 phosphorylation.Semantic proximity Read ↗

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferationSemantic proximity Read ↗

A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic ProliferationSemantic proximity Read ↗

Thrombopoietin: the Primary Regulator of Megakaryocyte and Platelet ProductionSemantic proximity Read ↗

miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient plateletsSemantic proximity Read ↗

CRISPR/Cas9-mediated deletion of Shp1 and Shp2 reveals distinct roles in human megakaryopoiesis and proplatelet formationSemantic proximity Read ↗

JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation.Semantic proximity Read ↗

Molecular mechanisms of megakaryopoiesisSemantic proximity Read ↗

Thrombopoietin-Induced Differentiation of a Human Megakaryoblastic Leukemia Cell Line, CMK, Involves Transcriptional Activation of p21 WAF1/Cip1 by STAT5Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.