Article
A collapsed non-native RNA folding state.
Nature structural biology - 1 May 2000
Buchmueller K L, Webb A E, Richardson D A, Weeks K M
Abstract excerpt
At physiological Mg2+ concentrations, the catalytic core of the bI5 group I intron does not fold into its native structure. In contrast, as judged by the global size, this RNA undergoes structural collapse at Mg 2+ concentrations much lower than required to drive folding of the RNA completely to the native state. The bI5 RNA therefore exists in equilibrium between expanded and collapsed non-native states. The...
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