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Article

The long-range P3 helix of the Tetrahymena ribozyme is disrupted during folding between the native and misfolded conformations.

Journal of molecular biology - 9 Aug 2013

Mitchell David, Jarmoskaite Inga, Seval Nikhil, Seifert Soenke, Russell Rick

Abstract excerpt

RNAs are prone to misfolding, but how misfolded structures are formed and resolved remains incompletely understood. The Tetrahymena group I intron ribozyme folds in vitro to a long-lived misfolded conformation (M) that includes extensive native structure but is proposed to differ in topology from the native state (N). A leading model predicts that exchange of the topologies requires unwinding of the long-range,...

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Identifiers

PMID: 23702292
DOI: 10.1016/j.jmb.2013.05.008
PMCID: PMC3706569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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