Multiple unfolding events during native folding of the Tetrahymena group I ribozyme.

Abstract excerpt

Despite the ubiquitous nature of misfolded intermediates in RNA folding, little is known about their physical properties or the folding transitions that allow them to continue folding productively. Folding of the Tetrahymena group I ribozyme includes sequential accumulation of two intermediates, termed I(trap) and misfolded (M). Here, we probe the structure and folding transition of I(trap) and compare them to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Base Sequence
• Share to Dimethyl Sulfoxide
• Share to Hydroxyl Radical