Article
RNA tertiary interactions mediate native collapse of a bacterial group I ribozyme.
Journal of molecular biology - 11 Nov 2005
Chauhan Seema, Caliskan Gokhan, Briber Robert M, Perez-Salas Ursula, Rangan Prashanth, Thirumalai D, Woodson Sarah A
Abstract excerpt
Large RNAs collapse into compact intermediates in the presence of counterions before folding to the native state. We previously found that collapse of a bacterial group I ribozyme correlates with the formation of helices within the ribozyme core, but occurs at Mg2+ concentrations too low to support stable tertiary structure and catalytic activity. Here, using small-angle X-ray scattering, we show that...
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