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Article

Principles of RNA compaction: insights from the equilibrium folding pathway of the P4-P6 RNA domain in monovalent cations.

Journal of molecular biology - 5 Nov 2004

Takamoto Keiji, Das Rhiju, He Qin, Doniach Sebastian, Brenowitz Michael, Herschlag Daniel, Chance Mark R

Abstract excerpt

Counterions are required for RNA folding, and divalent metal ions such as Mg(2+) are often critical. To dissect the role of counterions, we have compared global and local folding of wild-type and mutant variants of P4-P6 RNA derived from the Tetrahymena group I ribozyme in monovalent and in divalent metal ions. A remarkably simple picture of the folding thermodynamics emerges. The equilibrium folding pathway in...

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Identifiers

PMID: 15491606
DOI: 10.1016/j.jmb.2004.08.080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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