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Article

The yeast heat shock transcription factor changes conformation in response to superoxide and temperature.

Molecular biology of the cell - 1 May 2000

Lee S, Carlson T, Christian N, Lea K, Kedzie J, Reilly J P, Bonner J J

Abstract excerpt

In vitro DNA-binding assays demonstrate that the heat shock transcription factor (HSF) from the yeast Saccharomyces cerevisiae can adopt an altered conformation when stressed. This conformation, reflected in a change in electrophoretic mobility, requires that two HSF trimers be bound to DNA. Single trimers do not show this change, which appears to represent an alteration in the cooperative interactions between...

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Identifiers

PMID: 10793149
DOI: 10.1091/mbc.11.5.1753
PMCID: PMC14881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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