Article

Chromatin conformation remains stable upon extensive transcriptional changes driven by heat shock

2019-01-22

Abstract excerpt

Heat shock (HS) initiates rapid, extensive, and evolutionarily conserved changes in transcription that are accompanied by chromatin decondensation and nucleosome loss at heat shock loci. Here we have employed in situ Hi-C to determine how heat stress affects long-range chromatin conformation in human and Drosophila cells. We found that compartments, topologically-associated domains (TADs), and looping interactions...

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Literature Corpus work: d5afa3fb-b36b-5e6e-8610-621da48d4aaa
DOI: 10.1101/527838

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