Article
Dependence and independence of [PSI(+)] and [PIN(+)]: a two-prion system in yeast?
The EMBO journal - 2 May 2000
Derkatch I L, Bradley M E, Masse S V, Zadorsky S P, Polozkov G V, Inge-Vechtomov S G, Liebman S W
Abstract excerpt
The [PSI(+)] prion can be induced by overproduction of the complete Sup35 protein, but only in strains carrying the non-Mendelian [PIN(+)] determinant. Here we demonstrate that just as [psi (-)] strains can exist as [PIN(+)] and [pin(-)] variants, [PSI(+)] can also exist in the presence or absence of [PIN(+)]. [PSI(+)] and [PIN(+)] tend to be cured together, but can be lost separately. [PSI(+)]-related phenotypes...
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