Genetic and environmental factors affecting the de novo appearance of the [PSI+] prion in Saccharomyces cerevisiae.

doi:10.1093/genetics/147.2.507

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Article

Genetic and environmental factors affecting the de novo appearance of the [PSI+] prion in Saccharomyces cerevisiae.

Genetics - 1 Oct 1997

Derkatch I L, Bradley M E, Zhou P, Chernoff Y O, Liebman S W

Abstract excerpt

It has previously been shown that yeast prion [PSI+] is cured by GuHCl, although reports on reversibility of curing were contradictory. Here we show that GuHCl treatment of both [PSI+] and [psi-] yeast strains results in two classes of [psi-] derivatives: Pin+, in which [PSI+] can be reinduced by...

Topics

Fungal Proteins
Guanidine
Heat-Shock Proteins
Peptide Termination Factors
Phenotype
Prions
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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