Article
Non-Mendelian determinant [ISP+] in yeast is a nuclear-residing prion form of the global transcriptional regulator Sfp1.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 2010
Rogoza Tatyana, Goginashvili Alexander, Rodionova Sofia, Ivanov Maxim, Viktorovskaya Olga, Rubel Alexander, Volkov Kirill, Mironova Ludmila
Abstract excerpt
Four protein-based genetic determinants or prions-[SWI(+)], [MCA], [OCT(+)], and [MOT3(+)]-are recent additions to the list of well-known Saccharomyces cerevisiae prions, [PSI(+)], [URE3], and [PIN(+)]. A rapid expansion of this list may indicate that many yeast proteins can convert into heritable prion forms and underscores a problem of prion input into cellular physiology. Here, we prove that the global...
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