Article
[Psi(+)] prion generation in yeast: characterization of the 'strain' difference.
Yeast (Chichester, England) - 1 Apr 2001
Kochneva-Pervukhova N V, Chechenova M B, Valouev I A, Kushnirov V V, Smirnov V N, Ter-Avanesyan M D
Abstract excerpt
The yeast cytoplasmically-inherited nonsense suppressor [PSI(+)] determinant is presumed to be a manifestation of the aggregated prion-like state of the Sup35 protein. Overexpression of the Sup35 protein induces generation of [PSI(+)] determinants with various suppressor efficiency and mitotic stabilities. Here, we demonstrate that the relative frequency of appearance of [PSI(+)] with different properties depends...
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