Article
Prions affect the appearance of other prions: the story of [PIN(+)].
Cell - 27 Jul 2001
Derkatch I L, Bradley M E, Hong J Y, Liebman S W
Abstract excerpt
Prions are self-propagating protein conformations. Recent research brought insight into prion propagation, but how they first appear is unknown. We previously established that the yeast non-Mendelian trait [PIN(+)] is required for the de novo appearance of the [PSI(+)] prion. Here, we show that the presence of prions formed by Rnq1 or Ure2 is sufficient to make cells [PIN(+)]. Thus, [PIN(+)] can be caused by more...
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