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Article

Blocking the 4 integrin paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site

9 Feb 2006

Abstract excerpt

Antagonists to alpha4 integrin show promise for several autoimmune and inflammatory diseases but may exhibit mechanism-based toxicities. We tested the capacity of blockade of alpha4 integrin signaling to perturb functions involved in inflammation, while limiting potential adverse effects. We generated and characterized mice bearing a Y991A mutation in alpha4 integrin [alpha4(Y991A) mice], which blocks paxillin...

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PMID: 16470243
DOI: 10.1172/jci26091

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