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Article

The phospho-caveolin-1 scaffolding domain dampens force fluctuations in focal adhesions and promotes cancer cell migration.

Molecular biology of the cell - 1 Aug 2017

Meng Fanrui, Saxena Sandeep, Liu Youtao, Joshi Bharat, Wong Timothy H, Shankar Jay, Foster Leonard J, Bernatchez Pascal, Nabi Ivan R

Abstract excerpt

Caveolin-1 (Cav1), a major Src kinase substrate phosphorylated on tyrosine-14 (Y14), contains the highly conserved membrane-proximal caveolin scaffolding domain (CSD; amino acids 82-101). Here we show, using CSD mutants (F92A/V94A) and membrane-permeable CSD-competing peptides, that Src kinase-dependent pY14Cav1 regulation of focal adhesion protein stabilization, focal adhesion tension, and cancer cell migration...

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Identifiers

PMID: 28592633
DOI: 10.1091/mbc.E17-05-0278
PMCID: PMC5531735

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