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Article

Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach.

The Biochemical journal - 11 Nov 2009

Mould A Paul, Koper Ewa J, Byron Adam, Zahn Grit, Humphries Martin J

Abstract excerpt

Integrin alpha5beta1 is a key receptor for the extracellular matrix protein fibronectin. Antagonists of human integrin alpha5beta1 have therapeutic potential as anti-angiogenic agents in cancer and diseases of the eye. However, the structure of the integrin is unsolved and the atomic basis of fibronectin and antagonist binding by integrin alpha5beta1 is poorly understood. In the present study, we demonstrate that...

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Identifiers

PMID: 19747169
DOI: 10.1042/BJ20090992
PMCID: PMC3329623

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Source receipt: pubmed, retrieved 7 Sept 2026.

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