Article
Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain.
The Journal of cell biology - 19 Dec 2005
Alon Ronen, Feigelson Sara W, Manevich Eugenia, Rose David M, Schmitz Julia, Overby Darryl R, Winter Eitan, Grabovsky Valentin, Shinder Vera, Matthews Benjamin D, Sokolovsky-Eisenberg Maya, Ingber Donald E, Benoit Martin, Ginsberg Mark H
Abstract excerpt
The capacity of integrins to mediate adhesiveness is modulated by their cytoplasmic associations. In this study, we describe a novel mechanism by which alpha4-integrin adhesiveness is regulated by the cytoskeletal adaptor paxillin. A mutation of the alpha4 tail that disrupts paxillin binding, alpha4(Y991A), reduced talin association to the alpha4beta1 heterodimer, impaired integrin anchorage to the cytoskeleton,...
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