Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of transmission-ratio distortion on allele sharing in affected sibling pairs.

American journal of human genetics - 1 Jun 2000

Greenwood C M, Morgan K

Abstract excerpt

There have been recent reports of transmission-ratio distortion (TRD) or segregation distortion in families not selected for genetic disease. If TRD exists but is ignored, linkage studies searching for disease genes in affected relatives may be misinterpreted. We show that the identical-by-descent sharing patterns for affected sib pairs are strongly affected by TRD and, further, that the estimated statistical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bias
Share to Diabetes Mellitus, Type 1
Share to Genes, Dominant

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Diseases, Inborn

Share to Matched-Pair Analysis

Share to Nuclear Family

Share to Sample Size

Share to Sex Characteristics

Source

Open in PubMed Open full text

Identifiers

PMID: 10775526
DOI: 10.1086/302918
PMCID: PMC1378036

Genes

TRD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of transmission-ratio distortion on allele sharing in affected sibling pairs.PMID 10775526Read ↗

Transmission-ratio distortion and allele sharing in affected sib pairs: a new linkage statistic with reduced bias, with application to chromosome 6q25.3.Semantic proximity Read ↗

A systematic review and critical analysis of the evidence for transmission ratio distortion in humans.Semantic proximity Read ↗

Transmission ratio distortion: review of concept and implications for genetic association studies.Semantic proximity Read ↗

Transmission ratio distortion in families from the Framingham Heart Study.Semantic proximity Read ↗

Evidence for extensive transmission distortion in the human genome.Semantic proximity Read ↗

Distortion of Mendelian segregation across the Angus cattle genome uncovering regions affecting reproduction.Semantic proximity Read ↗

Identification of two maternal transmission ratio distortion loci in pedigrees of the Framingham heart study.Semantic proximity Read ↗

Discriminating between allele- and genotype-specific transmission ratio distortion.Semantic proximity Read ↗

Allele-sharing among affected relatives: non-parametric methods for identifying genes.Semantic proximity Read ↗

Testing for segregation distortion in the HLA complex.Semantic proximity Read ↗

Transmission ratio distortion in females on chromosome 10p11-p15.Semantic proximity Read ↗

Optimal allele-sharing statistics for genetic mapping using affected relatives.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.