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Article

Transmission ratio distortion in families from the Framingham Heart Study.

BMC genetics - 31 Dec 2003

Paterson Andrew D, Sun Lei, Liu Xiao-Qing

Abstract excerpt

BACKGROUND: One implicit assumption in most linkage analysis is that live-born siblings unselected for a phenotype do not share alleles greater than the Mendelian expectation at any particular locus. However, since most families are recruited for genetic studies because of the presence of disease, there is little data available to confirm that this is the case. We hypothesized that loci that behave in a...

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Identifiers

PMID: 14975116
DOI: 10.1186/1471-2156-4-S1-S48
PMCID: PMC1866484

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