Testing for segregation distortion in the HLA complex.

Article

Testing for segregation distortion in the HLA complex.

Biometrics - 1 Dec 1994

Jin K, Speed T P, Klitz W, Thomson G

Abstract excerpt

One of the long-standing issues in HLA research is whether there is segregation distortion in the HLA complex in human populations. In this paper we study some simple statistical models aimed at detecting segregation distortion. We present a statistic to test the Mendelian null hypothesis of equa...

Topics

Alleles
Biometry
Disease Susceptibility
Female
Genetic Predisposition to Disease
HLA-A Antigens
HLA-B Antigens
HLA-DR Antigens
Humans
Male
Models, Statistical
Nuclear Family
Probability

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