Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transmission-ratio distortion and allele sharing in affected sib pairs: a new linkage statistic with reduced bias, with application to chromosome 6q25.3.

American journal of human genetics - 1 Oct 2004

Lemire Mathieu, Roslin Nicole M, Laprise Catherine, Hudson Thomas J, Morgan Kenneth

Abstract excerpt

We studied the effect of transmission-ratio distortion (TRD) on tests of linkage based on allele sharing in affected sib pairs. We developed and implemented a discrete-trait allele-sharing test statistic, Sad, analogous to the Spairs test statistic of Whittemore and Halpern, that evaluates an exc...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Asthma
Share to Chromosomes, Human, Pair 6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Genetic Testing

Share to Inheritance Patterns

Share to Research Design

Share to Siblings

Source

Open in PubMed Open full text

Identifiers

PMID: 15322985
DOI: 10.1086/424528
PMCID: PMC1182045

Genes

TRD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15322985-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transmission-ratio distortion and allele sharing in affected sib pairs: a new linkage statistic with reduced bias, with application to chromosome 6q25.3.PMID 15322985Read ↗

The impact of transmission-ratio distortion on allele sharing in affected sibling pairs.Semantic proximity Read ↗

Transmission ratio distortion in families from the Framingham Heart Study.Semantic proximity Read ↗

A systematic review and critical analysis of the evidence for transmission ratio distortion in humans.Semantic proximity Read ↗

Genetic association mapping based on discordant sib pairs: the discordant-alleles test.Semantic proximity Read ↗

Evidence for extensive transmission distortion in the human genome.Semantic proximity Read ↗

Exploiting excess sharing: a more powerful test of linkage for affected sib pairs than the transmission/disequilibrium test.Semantic proximity Read ↗

Evaluating linkage and linkage disequilibrium: use of excess sharing and transmission disequilibrium methods in affected sib pairs.Semantic proximity Read ↗

Transmission ratio distortion: review of concept and implications for genetic association studies.Semantic proximity Read ↗

Allele-sharing among affected relatives: non-parametric methods for identifying genes.Semantic proximity Read ↗

Allele sharing and allelic association I: sib pair tests with increased power.Semantic proximity Read ↗

Assessing whether an allele can account in part for a linkage signal: the Genotype-IBD Sharing Test (GIST).Semantic proximity Read ↗

Hidden linkage: a comparison of the affected sib pair (ASP) test and transmission/disequilibrium test (TDT).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.