Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations.

doi:10.1038/ng0594-91

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Article

Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations.

Nature genetics - 1 May 1994

Bardeesy N, Falkoff D, Petruzzi M J, Nowak N, Zabel B, Adam M, Aguiar M C, Grundy P, Shows T, Pelletier J

Abstract excerpt

The genetics of Wilms' tumour (WT), a paediatric malignancy of the kidney, is complex. Inactivation of the tumour suppressor gene, WT1, is associated with tumour aetiology in approximately 10-15% of WTs. Chromosome 17p changes have been noted in cytogenetic studies of WTs, prompting us to screen...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Cell Differentiation
DNA Mutational Analysis
Female
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Kidney Neoplasms
Male
Molecular Sequence Data
Neoplasm Proteins
Nuclear Proteins
Polymerase Chain Reaction
Prognosis
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2

Source

Open in PubMed

Identifiers

PMID: 8075648
DOI: 10.1038/ng0594-91

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8075648-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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