Article
Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations.
Nature genetics - 1 May 1994
Bardeesy N, Falkoff D, Petruzzi M J, Nowak N, Zabel B, Adam M, Aguiar M C, Grundy P, Shows T, Pelletier J
Abstract excerpt
The genetics of Wilms' tumour (WT), a paediatric malignancy of the kidney, is complex. Inactivation of the tumour suppressor gene, WT1, is associated with tumour aetiology in approximately 10-15% of WTs. Chromosome 17p changes have been noted in cytogenetic studies of WTs, prompting us to screen 140 WTs for p53 mutations. When histopathology reports were available, p53 mutations were present in eight of eleven...
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