Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Infrequency of ras, p53, WT1, or RB gene alterations in Wilms tumors.

Cancer - 15 Dec 1993

Waber P G, Chen J, Nisen P D

Abstract excerpt

BACKGROUND: Alteration of the ras family of oncogenes and of the tumor suppressor genes p53 and RB are the most common genetic events in human tumors. Although there have been no reports of the prevalence of these alterations in Wilms tumors, overexpression of the N-myc and insulin-like growth factor-II (IGF-II) genes have been observed, and alteration of another tumor suppressor gene (WT1) has been demonstrated....

Topics

Base Sequence
Child, Preschool
Chromosome Deletion
DNA-Binding Proteins
Female
Genes, Retinoblastoma
Genes, p53
Genes, ras
Humans
Infant
Kidney Neoplasms
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

WT1 Proteins

Wilms Tumor

Source

Identifiers

PMID: 8252491
DOI: 10.1002/1097-0142(19931215)72:12<3732::aid-cncr2820721228>3.0.co;2-u

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8252491-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infrequency of ras, p53, WT1, or RB gene alterations in Wilms tumors.PMID 8252491Read ↗

Mutations of p53 in Wilms' tumors.Semantic proximity Read ↗

Analysis of the p53 gene by PCR-SSCP in ten cases of Wilms' tumor.Semantic proximity Read ↗

Low frequency of mutations in the WT1 coding region in Wilms' tumor.Semantic proximity Read ↗

Infrequent mutation of the WT1 gene in 77 Wilms' Tumors.Semantic proximity Read ↗

Infrequency of MDM2 gene amplification in pediatric solid tumors and lack of association with p53 mutations in adult squamous cell carcinomas.Semantic proximity Read ↗

Mutation analysis of p53 gene in childhood malignant solid tumors.Semantic proximity Read ↗

Immunohistochemical detection of p53 in Wilms' tumors correlates with unfavorable outcome.Semantic proximity Read ↗

Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene.Semantic proximity Read ↗

Immunophenotype, mRNA expression, and gene structure of p53 in Wilms' tumors.Semantic proximity Read ↗

Loss of heterozygosity at 11p13 in Wilms' tumours does not necessarily involve mutations in the WT1 gene.Semantic proximity Read ↗

Infrequent p53 gene mutations and lack of p53 protein expression in clear cell sarcoma of the kidney: immunohistochemical study and mutation analysis of p53 in renal tumors of unfavorable prognosis.Semantic proximity Read ↗

Chromosome analyses of 16 cases of Wilms tumor: different pattern in unfavorable histology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.