Article
Screening for germ line p53 mutations in children with malignant tumors and a family history of cancer.
Cancer research - 1 Feb 1993
Brugières L, Gardes M, Moutou C, Chompret A, Meresse V, Martin A, Poisson N, Flamant F, Bonaïti-Pellié C, Lemerle J
Abstract excerpt
We have undertaken a routine investigation of the p53 status for all the children treated at our institution either affected by multiple tumors or whose family displays at least one second degree relative or less, affected by cancer before the age of 45 years. We report here on the first set of ten such families, eight of which were identified through a proband with sarcoma. p53 exons 5 to 8 have been sequenced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.