Screening for germ line p53 mutations in children with malignant tumors and a family history of cancer.

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Article

Screening for germ line p53 mutations in children with malignant tumors and a family history of cancer.

Cancer research - 1 Feb 1993

Brugières L, Gardes M, Moutou C, Chompret A, Meresse V, Martin A, Poisson N, Flamant F, Bonaïti-Pellié C, Lemerle J

Abstract excerpt

We have undertaken a routine investigation of the p53 status for all the children treated at our institution either affected by multiple tumors or whose family displays at least one second degree relative or less, affected by cancer before the age of 45 years. We report here on the first set of t...

Topics

Adolescent
Adult
Alleles
Arginine
Base Sequence
Child
Child, Preschool
Exons
Family Health
Female
Genes, p53
Germ Cells
Glycine
Humans
Infant
Li-Fraumeni Syndrome
Male
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 8425176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8425176-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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