Article
Functional effects of periodic tryptophan substitutions in the alpha M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor.
Biochemistry - 25 Apr 2000
Tamamizu S, Guzmán G R, Santiago J, Rojas L V, McNamee M G, Lasalde-Dominicci J A
Abstract excerpt
Previous amino acid substitutions at the M4 domain of the Torpedo californica and mouse acetylcholine receptor suggested that the location of the substitution relative to the membrane-lipid interface and perhaps to the ion pore can be critical to the channel gating mechanism [Lasalde, J. A., Tamamizu, S., Butler, D. H., Vibat, C. R. T., Hung, B., and McNamee, M. G. (1996) Biochemistry 35, 14139-14148;...
Topics
- Acetylcholine
- Allosteric Site
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Bungarotoxins
- Dose-Response Relationship, Drug
- Electric Conductivity
- Gene Expression
- Ion Channel Gating
- Kinetics
- Models, Molecular
- Molecular Sequence Data