Mutations in the M4 domain of the Torpedo californica nicotinic acetylcholine receptor alter channel opening and closing.

doi:10.1007/s002329900240

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Article

Mutations in the M4 domain of the Torpedo californica nicotinic acetylcholine receptor alter channel opening and closing.

The Journal of membrane biology - 1 Jul 1997

Ortiz-Miranda S I, Lasalde J A, Pappone P A, McNamee M G

Abstract excerpt

We studied the functional effects of single amino acid substitutions in the postulated M4 transmembrane domains of Torpedo californica nicotinic acetylcholine receptors (nAChRs) expressed in Xenopus oocytes at the single-channel level. At low ACh concentrations and cold temperatures, the replacem...

Topics

Amino Acid Sequence
Animals
Ion Channel Gating
Mutation
Protein Structure, Tertiary
Receptors, Nicotinic
Sequence Homology, Amino Acid
Torpedo

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