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Article

The minimum M3-M4 loop length of neurotransmitter-activated pentameric receptors is critical for the structural integrity of cytoplasmic portals.

The Journal of biological chemistry - 26 Jul 2013

Baptista-Hon Daniel T, Deeb Tarek Z, Lambert Jeremy J, Peters John A, Hales Tim G

Abstract excerpt

The 5-HT3A receptor homology model, based on the partial structure of the nicotinic acetylcholine receptor from Torpedo marmorata, reveals an asymmetric ion channel with five portals framed by adjacent helical amphipathic (HA) stretches within the 114-residue loop between the M3 and M4 membrane-spanning domains. The positive charge of Arg-436, located within the HA stretch, is a rate-limiting determinant of...

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Identifiers

PMID: 23740249
DOI: 10.1074/jbc.M113.481689
PMCID: PMC3724616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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