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Article

The role of loop 5 in acetylcholine receptor channel gating.

The Journal of general physiology - 1 Nov 2003

Chakrapani Sudha, Bailey Timothy D, Auerbach Anthony

Abstract excerpt

Nicotinic acetylcholine receptor channel (AChR) gating is an organized sequence of molecular motions that couples a change in the affinity for ligands at the two transmitter binding sites with a change in the ionic conductance of the pore. Loop 5 (L5) is a nine-residue segment (mouse alpha-subunit 92-100) that links the beta4 and beta5 strands of the extracellular domain and that (in the alpha-subunit) contains...

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Identifiers

PMID: 14557402
DOI: 10.1085/jgp.200308885
PMCID: PMC2229574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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