Key roles of hydrophobic rings of TM2 in gating of the alpha9alpha10 nicotinic cholinergic receptor.

doi:10.1038/sj.bjp.0706224

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Article

Key roles of hydrophobic rings of TM2 in gating of the alpha9alpha10 nicotinic cholinergic receptor.

British journal of pharmacology - 1 Aug 2005

Plazas Paola V, De Rosa María J, Gomez-Casati María E, Verbitsky Miguel, Weisstaub Noelia, Katz Eleonora, Bouzat Cecilia, Elgoyhen Ana Belén

Abstract excerpt

We have performed a systematic mutagenesis of three hydrophobic rings (17', 13' and 9') within transmembrane region (TM) 2 of the alpha9alpha10 nicotinic cholinergic receptor (nAChR) to a hydrophilic (threonine) residue and compared the properties of mutant receptors reconstituted in Xenopus laevis oocytes. Phenotypic changes in alpha9alpha10 mutant receptors were evidenced by a decrease in the desensitization...

Topics

Acetylcholine
Allosteric Regulation
Amino Acid Sequence
Animals
Calcium
Cholinergic Agents
Dose-Response Relationship, Drug
Ion Channel Gating
Membrane Potentials
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Oocytes

Patch-Clamp Techniques

Phenotype

Protein Subunits

Receptors, Nicotinic

Recombinant Proteins

Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 15895110
DOI: 10.1038/sj.bjp.0706224
PMCID: PMC1576203

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