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Article

Key roles of hydrophobic rings of TM2 in gating of the alpha9alpha10 nicotinic cholinergic receptor.

British journal of pharmacology - 1 Aug 2005

Plazas Paola V, De Rosa María J, Gomez-Casati María E, Verbitsky Miguel, Weisstaub Noelia, Katz Eleonora, Bouzat Cecilia, Elgoyhen Ana Belén

Abstract excerpt

We have performed a systematic mutagenesis of three hydrophobic rings (17', 13' and 9') within transmembrane region (TM) 2 of the alpha9alpha10 nicotinic cholinergic receptor (nAChR) to a hydrophilic (threonine) residue and compared the properties of mutant receptors reconstituted in Xenopus laevis oocytes. Phenotypic changes in alpha9alpha10 mutant receptors were evidenced by a decrease in the desensitization...

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Identifiers

PMID: 15895110
DOI: 10.1038/sj.bjp.0706224
PMCID: PMC1576203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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