Article
Probing the effects of membrane cholesterol in the Torpedo californica acetylcholine receptor and the novel lipid-exposed mutation alpha C418W in Xenopus oocytes.
The Journal of biological chemistry - 7 Dec 2001
Santiago J, Guzmàn G R, Rojas L V, Marti R, Asmar-Rovira G A, Santana L F, McNamee M, Lasalde-Dominicci J A
Abstract excerpt
The effects of cholesterol on the ion-channel function of the Torpedo acetylcholine receptor (nAChR) and the novel lipid-exposed gain in function alpha C418W mutation have been investigated in Xenopus laevis oocytes. We found conditions to increase the cholesterol/phospholipid (C/P) molar ratio on the plasma membrane of Xenopus oocytes from 0.5 to 0.87, without significant physical damage or change in morphology...
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