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Article

Role of the N-terminal alpha-helix in biogenesis of alpha7 nicotinic receptors.

Journal of neurochemistry - 1 Mar 2009

Castillo Mar, Mulet José, Aldea Marcos, Gerber Susana, Sala Salvador, Sala Francisco, Criado Manuel

Abstract excerpt

We studied the role of the alpha-helix present at the N-terminus of nicotinic acetylcholine receptor (nAChR) subunits in the expression of functional channels. Deletion of this motif in alpha7 subunits abolished expression of nAChRs at the membrane of Xenopus oocytes. The same effect was observed upon substitution by homologous motifs of other ligand-gated receptors. When residues from Gln4 to Tyr15 were...

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Source

Identifiers

PMID: 19166504
DOI: 10.1111/j.1471-4159.2009.05924.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Role of the N-terminal alpha-helix in biogenesis of alpha7 nicotinic receptors.PMID 19166504Read ↗

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