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Article

Mutations at lipid-exposed residues of the acetylcholine receptor affect its gating kinetics.

Molecular pharmacology - 1 Jul 1998

Bouzat C, Roccamo A M, Garbus I, Barrantes F J

Abstract excerpt

The firmest candidate among the transmembrane portions of the nicotinic acetylcholine receptor (AChR) to be in contact with the lipid bilayer is the fourth segment, M4. To explore the contribution of alphaM4 amino acid residues of mouse AChR to channel gating, we combined site-directed mutagenesis with single-channel recordings. Two residues in alphaM4, Cys418 and Thr422, were found to significantly affect gating...

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PMID: 9658200
DOI: 10.1124/mol.54.1.146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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