Mutations at lipid-exposed residues of the acetylcholine receptor affect its gating kinetics.

doi:10.1124/mol.54.1.146

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Article

Mutations at lipid-exposed residues of the acetylcholine receptor affect its gating kinetics.

Molecular pharmacology - 1 Jul 1998

Bouzat C, Roccamo A M, Garbus I, Barrantes F J

Abstract excerpt

The firmest candidate among the transmembrane portions of the nicotinic acetylcholine receptor (AChR) to be in contact with the lipid bilayer is the fourth segment, M4. To explore the contribution of alphaM4 amino acid residues of mouse AChR to channel gating, we combined site-directed mutagenesi...

Topics

Alanine
Amino Acid Sequence
Animals
Cells, Cultured
Ion Channel Gating
Lipid Bilayers
Mice
Molecular Sequence Data
Mutation
Receptor, Muscarinic M4
Receptors, Cholinergic
Receptors, Muscarinic
Sequence Alignment
Sequence Homology, Amino Acid

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