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Forkhead/winged-helix transcription factor whn regulates hair keratin gene expression: Molecular analysis of theNude skin phenotype

1 Apr 2000

Abstract excerpt

The molecular characteristics of the nude phenotype (alopecia and thymic aplasia) in humans and rodents are unknown. The nude locus encodes Whn, a transcription factor of the forkhead/winged-helix class. Expression of Whn in HeLa cells induced expression of human hair keratin genes Ha3-II and Hb5. Correspondingly, in nude mice, which are homozygous for a loss-of-function mutation of Whn, expression of mouse mHa3...

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Identifiers

PMID: 10767081
DOI: 10.1002/(sici)1097-0177(200004)217:4<368::aid-dvdy4>3.0.co;2-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Forkhead/winged-helix transcription factor whn regulates hair keratin gene expression: Molecular analysis of theNude skin phenotypePMID 10767081Read ↗

Genetically separable determinants of hair keratin gene expression.Semantic proximity Read ↗

New member of the winged-helix protein family disrupted in mouse and rat nude mutations.Semantic proximity Read ↗

The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain.Semantic proximity Read ↗

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A Drosophila Winged-helix nude (Whn)-like transcription factor with essential functions throughout development.Semantic proximity Read ↗

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The <i>nude</i> gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune systemSemantic proximity Read ↗

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Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product.Semantic proximity Read ↗

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