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Article

New member of the winged-helix protein family disrupted in mouse and rat nude mutations.

Nature - 3 Nov 1994

Nehls M, Pfeifer D, Schorpp M, Hedrich H, Boehm T

Abstract excerpt

Mutations at the nude locus of mice and rats disrupt normal hair growth and thymus development, causing nude mice and rats to be immune-deficient. The mouse nude locus has been localized on chromosome 11 (refs 3, 4) within a region of < 1 megabase. Here we show that one of the genes from this critical region, designated whn, encodes a new member of the winged-helix domain family of transcription factors, and that...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Chromosome Mapping
DNA-Binding Proteins
Embryonic and Fetal Development
Forkhead Transcription Factors
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Nude

Molecular Sequence Data

Rats

Rats, Nude

Transcription Factors

Source

Identifiers

PMID: 7969402
DOI: 10.1038/372103a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7969402-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

New member of the winged-helix protein family disrupted in mouse and rat nude mutations.PMID 7969402Read ↗

A Drosophila Winged-helix nude (Whn)-like transcription factor with essential functions throughout development.Semantic proximity Read ↗

Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat.Semantic proximity Read ↗

The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain.Semantic proximity Read ↗

Forkhead/winged-helix transcription factor whn regulates hair keratin gene expression: Molecular analysis of theNude skin phenotypeSemantic proximity Read ↗

The <i>nude</i> gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune systemSemantic proximity Read ↗

Genetically separable determinants of hair keratin gene expression.Semantic proximity Read ↗

Pillars article: new member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature. 1994. 372: 103-107.Semantic proximity Read ↗

Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-type Hfh11 genomic locus.Semantic proximity Read ↗

Ectopic expression of the nude gene induces hyperproliferation and defects in differentiation: implications for the self-renewal of cutaneous epithelia.Semantic proximity Read ↗

Expression domains in the skin of genes affected by the nude mutation and identified by gene expression profiling.Semantic proximity Read ↗

FOXN1 Deficiency: from the Discovery to Novel Therapeutic Approaches.Semantic proximity Read ↗

A zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment.Semantic proximity Read ↗

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